2019

  • Ssu72 phosphatase is a conserved telomere replication terminator.
    Escandell JM, Carvalho ES, Gallo-Fernandez M, Reis CC, Matmati S, Luís IM, Abreu IA, Coulon S, Miguel G Ferreira. EMBO J. 2019 Apr 1;38(7). pii: e100476. doi: 10.15252/embj.2018100476. Epub 2019 Feb 21. PMID: 30796050
  • Inheritance of a phenotypically neutral epimutation evokes gene silencing in later generations.
    Duempelmann L, Mohn F, Shimada Y, Oberti D, Andriolloa A, Lochs S, Marc Bühler. Mol. Cell 2019 Mar 5. pii: S1097-2765(19)30099-1. doi: 10.1016/j.molcel.2019.02.009. PMID: 30898439 JC Mar 26 2019
  • A non-enzymatic function associated with a putative histone demethylase licenses epigenetic inheritance.
    Raiymbek G, An S, Khurana N, Gopinath S, Trievel R, Cho US, Kaushik Ragunathan. BioRxiv Feb 19.
  • Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1.
    Leopold K, Stirpe A, Thomas Schalch. Genes Dev 2019 Feb 26. doi: 10.1101/gad.320440.118. PMID: 30808655 JC Mar 5 2019
  • Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression.
    Padeken J, Zeller P, Towbin B, Katic I, Kalck V, Methot SP, Susan M Gasser SM.
    Genes Dev 2019 Feb 25. doi: 10.1101/gad.322495.118. PMID: 30804228
  • An RNA aptamer to HP1/Swi6 facilitates heterochromatin formation at an ectopic locus in S.pombe.
    Rani R, Yassen AM, Aarti Sevilimedu. RNA Biology 2019 Feb 22:1-12. doi: 10.1080/15476286.2019.1584026. PMID: 30794054.
  • An essential role for dTNP homeostasis following CDK-induced replication stress.
    Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, … Bähler J, Carr AM, Tim C. Humphrey.
    J Cell Sci. 2019 Feb 15. pii: jcs.226969. doi: 10.1242/jcs.226969 PMID: 30674555
  • RAD52 and SLX4 act nonepistatically to enures telomere stability during alternative telomere lengthening.
    Verma P, Dilley RL, Zhang, T, Gyparaki MT, Li Y, Roger A Greenberg. Genes Dev. 2019 Feb 1;33(3-4):221-235. doi: 10.1101/gad.319723.118. Epub 2019 Jan 28. PMID: 30692206
  • Alternative lengthening of telomeres through two distinct break-induced replication pathways.
    Zhang JM, Ydav T, Ouyang J, Lan L, Lee Zou. Cell Rep. 2019 Jan 22;26(4):955-968.e3. doi: 10.1016/j.celrep.2018.12.102. PMID: 30673617
  • A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing.
    Xie G, Vo TV, Thilainadesan G, Holla S Zhang B, Jiang Y, Lv M, Xy Z Wang C, Balachandran V, Shi Y, Fudong Li, Shiv Grewal.   Nat Commun. 2019 Jan 16; 10(1):251. doi: 10.1038/s41467-018-08273-9. PMID: 30651569 JC Jan 29 2019
  • H3K9me3-heterochromatin loss at protein-coding genes enables devlopmental lineage specification.
    Nicetto D, Donahue G, Jain T …  Bonasio R, Jenuwein T, and Ken Zaret.   Science 2019 Jan 18;363(6424):294-297. doi: 10.1126/science.aau0583. Epub 2019 Jan 3. PMID: 30606806
  • RNA-binding porteins distinguish between similar sequences motifs to promote targeted deadeynlation by Ccr4-Not. Webster MW, Stowell JA, Lori Passmore. Elife 2019 Jan 2;8. pii: e40670. doi: 10.7554/eLife.40670. PMID: 30601114
  • Anti-Silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.
    Bao K, Shan CM, Moresco J, Yates J 3rd, Songtao Jia.   Genes Dev. 2019 Jan 1; 33(1-2) . 0.1101/gad.318030.118. Epub 2018 Dec 20. PMID: 30573453 JC Jan 8 2019

2018

  • Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.
    Hu C, Inoue H, Sun W, Takeshita Y, Huang Y, Xu Y, Kanoh J, Yong Chen.
    Nucleic Acids Res. 2018 Nov 20. doi: 10.1093/nar/gky1186 PMID: 304623017 JC Nov 27 2018
  • Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
    Telekawa C, Boisvert FM, Telekawa C, Boisvert FM, Francois Bachand.
    Nucleic Acids Res. 2018 Oct 13. doi: 10.1093/nar/gky915. PMID: 30321377
  • Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation.
    Marcomini I, Shimada K, Delgoshaie N, Yamamoto I, Seeber A, Cheblal A, Horigome C, Naumann U, Susan M Gasser.   Cell Rep. 2018 Sep 4;24(10):2614-2628.e4. PMID:30184497 JC Sept 25 2018
  • Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stabilty.
    Iglesias N, Currie MA, Jih G, Paula JA, Siuti N, Kolcsay M, Gyig SP, Danesh Moazed.
    Nature. 2018 Aug 23; 560(7719). PMID: 30051891 JC Nov 6 2018
  • The binding of Chp2’s chromodomain to methylated H3K9 is essential for Chp2’s role in heterochromatin assembly in fission yeast.
    Maksimov V, Oya E, Tanaka M, Kawaguchi T, Hachisuka A, Ekwall K, Bjerling P, Jun-ichi Nakayama.
    PLoS One. 2018 Aug 15;13(8):e0201101. eCollection 2018. PMID: 30110338
  • Long non-coding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.
    Atkinson SR1, Marguerat S1,2,3, Bitton DA1, Rodríguez-López M1, Rallis C1, Lemay JF4, Cotobal C1, Malecki M1, Smialowski P5, Mata J6, Korber P5, Bachand F4, Jürg Bähler1. RNA 2018 Sep;24(9):1195-1213. doi: 10.1261/rna.065524.118. Epub 2018 Jun 18. PMID: 29914874
  • Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.
    Yang J, Sun S, Zhang S, Gonzalez M, Dong Q, Chi Z, Chen YH, Fei Li. JC Sept4 6 2018
    PLoS Genet. 2018 Aug 8;14(8):e1007572. PMID:30089114
  • Ccp1 modulates epigenetic stability at centromeres and affects heterochromatin distribution in Schizosaccharomyces pombe.
    Lu M, Xiangwei He. JBC 2018 Aug 3;293(31):12068-12080. doi: 10.1074/jbc.RA118.003873. PMID: 29899117. JC Jun 4 2019
  • Shelterin promotes tethering of late replication origins to telomeres for replication-timing control.
    Ogawa S, Kido S, Handa T, Ogawa H, Asakawa H, Takahashi TS, Nakagawa T, Hiraoka Y, Masukata H.
    EMBO J. 2018 Aug 1;37(15). PMID: 29997179
  • Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
    Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Danesh Moazed
    Nature. 2018 Aug;560(7719):504-508. PMID: 30051891 JC Nov 6 2018
  • Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA. Greenwood J, Patel H, Cech TR, Julie Cooper.
    Nucleic Acids Res. 2018 Jul 10. [Epub ahead of print].  PMID: 29992245 JC Dec 18 2018
  • Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.
    Greenstein RA, Jones SK, Spivey EC, Rybarski JR, Finkelstein IJ, Bassem Al-Sady
    Elife. 2018 Jul 18;7. PMID: 30020075
  • Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly.
    Parsa JY, Boudoukha S, Burke J, Homer C, Hiten Madhani
    Genes Dev. 2018 Jul 1;32(13-14):953-964.  PMID: 29967291  JC Oct 2 2018
  • The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast. Seo HD, Kwon CS, Daeyoup Lee.
    Current Genetics. 2018 Jun 64;3. PMID: 29214404
  • Histone deacetylation promotes transcriptional silencing at facultative heterochromatin.
    Watts BR, Wittmann S, Wery M, Gautier C, Kus K, Birot A, Heo DH, Kilchert C, Morillon A, Lydia Vasiljeva.   Nucleic Acids Res. 2018 Jun 20;46(11):5426-5440. PMID:29618061  JC May 29 2018
  • Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.
    Yu R, Wang X, Danesh Moazed.   Nature. 2018 Jun;558(7711):615-619. PMID: 29925950 JC Feb  26 2019
  • TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.
    Cohen A, Habib A, Laor D, Yadav S, Kupiec M, Ronit Weisman
    J Biol Chem. 2018 May 25;293(21):8138-8150. PMID:29632066
  • Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control.
    Gallagher PS, Larkin M, Thillainadesan G, Dhakshnamoorthy J, Balachandran V, Xiao H, Wellman C, Chatterjee R, Wheeler D, Shiv Grewal.   Nat Struct Mol Biol. 2018 May;25(5):372-383. PMID:29686279 JC Nov 13 2018
  • Distinct ‘safe zones’ at the nuclear envelope ensure robust replication of heterochromatic chromosome regions.
    Ebrahimi H, Masuda H, Jain D, Julie Cooper.
    Elife.
    2018 May 3;7. PMID:29722648  JC Jul 24 2018
  • Ten principles of heterochromatin formation and function. Review.
    Allshire RC, Madhani HD.
    Nat Rev Mol Cell Biol.
    2018 Apr;19(4):229-244. PMID:29235574.
  • RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes.
    Begnis M, Apte MS, Masuda H, Jain D, Wheeler DL, Julie Cooper.
    Genes Dev. 2018 Apr 1;32(7-8):537-554.PMID:29654060  JC May 22 2018
  • The conserved histone variant H2A.Z illuminates meiotic recombination initiation.
    Yamada S, Kugou K, Ding DQ, Fujita Y, Yasushi Hiraoka, Murakami H, Ohta K, Yamada T.
    Curr Genet. 2018 Mar 16. PMID: 29549582
  • Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast.
    Páez-Moscoso DJ, Pan L, Sigauke RF, Schroeder MR, Tang W, Peter Baumann.
    Nat Commun. 2018 Feb 8;9(1):587. doi: 10.1038/s41467-017-02284-8. PMID: 29422664 JC Apr 30 2019
  • Unexpected roles of a shugoshin protein at subtelomeres.
    Junko Kanoh.   Genes Genet Syst. 2018 Jan 20;92(3):127-133. PMID: 28794351
  • Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast.
    Hirano Y, Kinugasa Y, Asakawa H, Chikashige Y, Obuse C, Haraguchi T, Yasushi Hiraoka.
    Genes Cells. 2018 Mar;23(3):122-135. Epub 2018 Jan 2. PMID:29292846  JC Jan 23 2018
  • Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast.
    Ren B, Tan HL, Nguyen TTT, Sayed AM, Li Y, Mok YK, Yang H, Ee Sin Chen.
    Nucleic Acids Res. 2018 Jan 9;46(1):189-202. PMID:29136238  JC Dec 12 2017

2017

  • Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi.
    Kajitani T, Kato H, Chikashige Y, Tsutsumi C, Hiraoka Y, Kimura H, Ohkawa Y, Obuse C, Hermand D, Yota Murakami
    Proc Natl Acad Sci U S A. 2017 Dec 26;114(52). PMID: 29237752
  • Host factors that promote retrotransposon integration are similar in distantly related eukaryotes.
    Rai SK, Sangesland M, Lee M, Esnault C, Cui Y, Chatterjee AG, Henry L. Levin. PLOS Genetics 2017 Dec 12;13(12):e1006775. doi: 10.1371/journal.pgen.1006775. PMID: 29232693 
  • Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences.
    Maestroni L, Audry J, Matmati S, Arcangioli B, Géli V, Stephane Coulon.
    Nat Commun. 2017 Nov 22;8(1):1684. PMID: 29167439  JC Dec 19 2017
  • The Ino80 complex mediates epigenetic centromere propagatio via active removal of histone H3.
    Choi ES, Cheon Y, Kang K, Daeyoup Lee.
    Nat Commun.
    2017 Sep 13;8(1):529. PMID:28904333  JC Feb 20 2018
  • Ubiquitination-dependent control of sexual differenation in fission yeast.
    Simonetti F, Candelli T, Leon S, Libri D, Mathieu Rougemaille
    eLIFE.
    2017;6:e28046. PMID:28841135 JC Sept 11 2018
  • Accumulation of RNA on chromatin disrupts heterochromatic silencing.
    Brönner C, Salvi L, Zocco M, Ugolini I, Mario Halic.
    Genome Res.
    2017 Jul;27(7):1174-1183. PMID:28404620  JC June 20 2018
  • LTR-Retrotransposon Control by rRNA-Derived Small RNAs.
    Schorn AJ, Gutbrod MJ, LeBlanc C, Rob Martienssen.
    Cell. 2017 Jun 29;170(1):61-71.e11. PMID:28666125  JC Nov 14 2017
  • DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 mehtylation.
    Wang X,  Danesh Moazed.
    Science. 2017 Apr 7, 356(6333). PMID: 28302794  JC Nov 24 2017
  • Chromatin remodeller Fun30 (Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation.
    Lee J, Choi ES, Seo HD, Kang K, Gilmore JM, Florens L, Washburn MP, Choe J, Workman JL, Daeyoup Lee.
    Nat Commun. 2017 Feb 20;8:14527.PMID:28218250  JC March 14 2017