Relocation of rDNA repeats for repair is dependent on SUMO-mediated nucleolar release by the Cdc48/p97 segregase
Matías Capella, Imke K. Mandemaker, Fabian den Brave, Lucía Martín Caballero, Boris Pfander, Andreas G. Ladurner, Stefan Jentsch, Sigurd Braun
bioRxiv 2021.01.05.425376; doi: https://doi.org/10.1101/2021.01.05.425376

Crosstalk between H2A variant-specific modifications impacts vital cell functions
Anna Schmücker, Bingkun Lei, Zdravko J. Lorković, Matías Capella, Sigurd Braun, Pierre Bourguet, Olivier Mathieu, Karl Mechtler, Frédéric Berger
bioRxiv 2021.01.14.426637; doi: https://doi.org/10.1101/2021.01.14.426637

A Synthetic Approach to Reconstruct the Evolutionary and Functional Innovations of the Plant Histone Variant H2A.W.
Bingkun Lei, Matías Capella, Sean A Montgomery, Michael Borg, Akihisa Osakabe, Malgorzata Goiser, Abubakar MuhammadSigurd Braun, Frédéric Berger
Current Biology 2021 Jan 11;31(1):182-191.e5. doi: 10.1016/j.cub.2020.09.080.


ESCRT recruitment by the inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
Capella M, Martín Caballero L, Pfander B, Braun S*, and Jentsch S.
J Cell Sci. 2020 Dec 21;133(24):jcs250688. doi: 10.1242/jcs.250688.
See also additional information on first-author Matías Capella

Local chromatin context dictates the genetic determinants of the heterochromatin spreading reaction.
Greenstein RA, Ng H, Barrales RR, Tan C, Braun S, and Al-Sady B
bioRxiv 2020 doi.org/10.1101/2020.05.26.117143 (preprint)

ESCRTing Heterochromatin Out of the Nuclear Periphery.
Capella M and Braun S
Developmental Cell Volume 53, Issue 1, 6 April 2020, Pages 3-5

The euchromatic histone mark H3K36me3 preserves heterochromatin through sequestration of an acetyltransferase complex in fission yeast.
Georgescu PR, Capella M, Fischer-Burkart S and Braun S
Microbial Cell 2020 Vol. 7, No. 3, pp. 80 – 92; doi: 10.15698/mic2020.03.711

Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability.
Greenstein RA, Barrales RR, Sanchez NA, Bisanz JE, Braun S, Al-Sady B
Genes & Development 2019 Dec 5. doi: 10.1101/gad.328468.119.

Neutral epigenetic inheritance: being prepared for future generations.
Capella M and Braun S.
Nat Struct Mol Biol 2019 May 20. doi: 10.1038/s41594-019-0239-5.

TASks for subtelomeres: when nucleosome loss and genome instability are favored.
van Emden TS and Braun S
Curren Genetics 2019 May 7. doi: 10.1007/s00294-019-00986-8.

Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability.
van Emden TS*, Forn M*, Forné I, Sarkadi Z, Capella M, Martín Caballero L, Fischer-Burkart S,  Brönner C, Simonetta M, Toczyski D, Halic M, Imhof A, and Braun S
EMBO Reports 2019 Jan;20(1). pii: e47181. doi: 10.15252/embr.201847181 *co-first authors


The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S, Gallardo P, Barrales RR, Braun S, Daga RR.
J Cell Biol. 2017 Oct 3. doi: 10.1083/jcb.201612194.

The histone acetyltransferase Mst2 protects active chromatin from epigenetic silencing by acetylating the ubiquitin ligase Brl1.
Flury V, Georgescu PR, Iesmantavicius V, Shimada Y, Kuzdere T, Braun S*, and Bühler M*
Molecular Cell
2017 Jul 20;67(2):294-307.e9. doi: 10.1016/j.molcel.2017.05.026. *co-corresponding authors

Beyond Tethering and the LEM domain: MSCellaneous functions of the inner nuclear membrane Lem2.
Braun S*, Barrales RR.
Nucleus 2016 Nov;7(6):523-531 doi: 10.1080/19491034.2016.1252892.
*corresponding author

Chromatin binding and silencing: Two roles of the same protein Lem2.
Barrales RR , Braun S.
Microbial Cell 2016 Apr 4;3(4):185-188 doi: 10.15698/mic2016.04.495.

Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics.
Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD.
PLoS One 2016 Aug 1;11(8):e0159292.

Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.
Barrales RRForn MGeorgescu PRSarkadi Z, and Braun S.
Genes & Develpment 2016 Jan 15;30(2):133-48.. doi: 10.1101/gad.271288.115


Global regulation of heterochromatin spreading by Leo1.
Verrier L, Taglini F, Barrales RR, Webb S, Urano T, Braun S, and Bayne EH.
Open Biology 2015 May;5(5): pii: 150045. doi: 10.1098/rsob.150045.

Relationship between genome and epigenome—challenges and requirements for future research.
Almouzni G, Altucci, L, Amati B, Ashley N, Baulcombe D, Beaujean N, Bock C, Bongcam-Rudloff E, Bousquet J, Braun S et al.
BMC Genomics 2014 Jun 18;15:487. doi: 10.1186/1471-2164-15-487.

Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.
Braun S*  and Madhani HD.
EMBO Reports 2012 Dec;13(12):1152. doi: 10.1038/embor.2012.78. *corresponding author


Postdoctoral work

Ers1 links HP1 to RNAi.
Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11258-63. doi: 10.1073/pnas.1204947109

The ubiquitin ligase Cul4-Ddb1Cdt2 inhibits the invasion of a boundary-associated anti-silencing factor into heterochromatin.
Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD.
Cell 2011 Jan 7;144(1):41-54. doi: 10.1016/j.cell.2010.11.051.

Ers1, a rapidly diverging protein essential for RNA interference-dependent heterochromatic silencing in Schizosaccharomyces pombe.
Rougemaille M, Shankar S, Braun S, Rowley M, Madhani HD.
J Biol Chem. 2008 Sep 19;283(38):25770-3. doi: 10.1074/jbc.C800140200

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.
Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS. 
Nat Methods 2008 Aug;5(8):711-8. doi: 10.1038/nmeth.1234.


PhD & before

SM-protein-controlled ER-associated degradation discriminates between different SNAREs.
Braun S, Jentsch S.
EMBO Reports 2007 Dec;8(12):1176-82.

A Series of Ubiquitin-Binding Factors Connects Cdc48/p97 to Substrate Multiubiquitylation and Proteasomal Targeting.
Richly H, Rape M, Braun S, Rumpf S, Hoege C and Jentsch S.
Cell 2005 Jan 14;120(1):73-84.

Role of the Ubiquitin-selective Cdc48Ufd1-Npl4 chaperone (segregase) in ERAD of Ole1 and other substrates.
Braun S, Matuschweski K, Rape M, Thoms S and Jentsch S.
EMBO Journal 2002 Feb 15;21(4):615-21.

Dexamethasone-enhanced sensitivity of mouse hippocampal HT22 cells for oxidative stress is associated with the suppression of nuclear factor-kappaB.
Braun S, Liebetrau W, Berning B, Behl C.
Neuroscience Letters 2000 Dec 8;295(3):101-4.

Glutathione and a UV light-induced glutathione S-transferase are involved in signaling to chalcone synthase in cell cultures.
Loyall L, Uchida K, Braun S, Furuya M, Frohnmeyer H.
Plant Cell 2000 Oct;12(10):1939-50.