2020

Epigenetic gene silencing by heterochromatin primes fungal resistance. Sito Torres-Garcia, Imtiyaz Yaseen, Manu Shukla, Pauline N. C. B. Audergon, Sharon A. White, Alison L. Pidoux & Robin C. Allshire. Nature (2020 Sept 9). https://www.nature.com/articles/s41586-020-2706-x?s=09

Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription. LauraSánchez-Mir, RodrigoFraile, JoséAyté, ElenaHidalgo. Journal of Molecular Biology. (2020 Sept 4). https://doi.org/10.1016/j.jmb.2020.08.004

Integrity of a heterochromatic domain ensured by its boundary elements. Sebastian Jespersen Charlton, Maria Mønster Jørgensen, and Geneviève Thon. Charlton, S. J., Jorgensen, M. M., Thon, G.
Proc. Natl. Acad. Sci. USA. (2020 Aug 17). https://doi.org/10.1073/pnas.2010062117

High-throughput identification of nuclear envelope protein interactions in Schizosaccharomyces pombe using an arrayed membrane yeast-two hybrid library. Joseph M. Varberg, Jennifer M. Gardner, Scott McCroskey, Snehabala Saravanan, William D. Bradford, Sue L. Jaspersen. bioRxiv (2020 July 30). https://doi.org/10.1101/2020.07.29.227819

Phase separation enables heterochromatin domains to do mechanical work. Jessica F. Williams, Ivan V. Surovtsev, Sarah M. Schreiner, Hang Nguyen, Yan Hu, Simon G.J. Mochrie, and Megan C. King. bioRxiv (2020 July 03). https://doi.org/10.1101/2020.07.02.184127

The histone H3-H4 tetramer is a copperreductase enzyme. Narsis Attar, Oscar A. Campos, Maria Vogelauer, Chen Cheng, Yong Xue,Stefan Schmollinger, Lukasz Salwinski, Nathan V. Mallipeddi, Brandon A. Boone, Linda Yen, Sichen Yang, Shannon Zikovich, Jade Dardine, Michael F. Carey, Sabeeha S. Merchant, Siavash K. Kurdistani. Science (2020 July 03). DOI: 10.1126/science.aba8740

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation. Marina Vietri, Sebastian W. Schultz, Aurélie Bellanger, Carl M. Jones, Louise I. Petersen, Camilla Raiborg, Ellen Skarpen, Christeen Ramane J. Pedurupillay, Ingrid Kjos, Eline Kip, Romy Timmer, Ashish Jain, Philippe Collas, Roland L. Knorr, Sushma N. Grellscheid, Halim Kusumaatmaja, Andreas Brech, Francesca Micci, Harald Stenmark & Coen Campsteijn. Nature Cell Biology (2020 June 29). https://doi.org/10.1038/s41556-020-0537-5

Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3. Adam Burton, Vincent Brochard, Carmen Galan, Elias R. Ruiz-Morales, Quirze Rovira, Diego Rodriguez-Terrones, Kai Kruse, Stéphanie Le Gras, Vishnu S. Udayakumar, Hang Gyeong Chin, André Eid, Xiaoyu Liu, Chenfei Wang, Shaorong Gao, Sriharsa Pradhan, Juan M. Vaquerizas, Nathalie Beaujean, Thomas Jenuwein & Maria-Elena Torres-Padilla. Nature Cell Biology (2020 June 29). https://doi.org/10.1038/s41556-020-0536-6

Molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast. Li Sun, Xiao-min Liu, Wen-zhu Li, Yuan-yuan Yi, Xiangwei He, Yamei Wang, Quan-wen Jin. Journal of Cell Science (2020 June 4). doi: 10.1242/jcs.244863

A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin. Gergana Shipkovenska, Alexander Durango, Marian Kalocsay, Steven P Gygi, Danesh Moazed. eLife (2020 June 3). https://elifesciences.org/articles/54341

Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum. Y. Hirano, Y. Kinugasa, H. Osakada, T. Shindo, Y. Kubota, S. Shibata, T. Haraguchi, Y. Hiraoka. Nature Communications (2020 June 1). https://doi.org/10.1038/s42003-020-0999-9

ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA. Phillip A. Dumesic, Caitlin I. Stoddart, Sandra Catania, Geeta J. Narlikar, Hiten D. Madhani. Molecular Cell (2020 May 20). https://doi.org/10.1016/j.molcel.2020.04.029

Conserved protein Pir2ARS2mediates gene repression through cryptic introns in lncRNAs. Gobi Thillainadesan1, Hua Xiao1, Sahana Holla1, Jothy Dhakshnamoorthy1, Lisa M. Miller Jenkins2,David Wheeler1& Shiv I. S. Grewal. Nature Communications (2020 May 15). https://doi.org/10.1038/s41467-020-16280-y

Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory. Poonam Bheda1, Diana Aguilar-Gómez123, Nils B.Becker411, JohannesBecker511, EmmanouilStavrou6, IgorKukhtevich1, ThomasHöfer4, SebastianMaerkl5, GillesCharvin7, CarstenMarr8, AntonisKirmizis6, RobertSchneider191012. Molecular Cell (2020 May 8). https://doi.org/10.1016/j.molcel.2020.04.016

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation. Alexander von Appen, Dollie LaJoie, Isabel E. Johnson, Michael J. Trnka, Sarah M. Pick, Alma L. Burlingame, Katharine S. Ullman & Adam Frost. Nature (2020 April 29). https://doi.org/10.1038/s41586-020-2232-x

Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast. Hayato Tsuyuzaki, Masahito Hosokawa, Koji Arikawa, Takuya Yoda, Naoyuki Okada, Haruko Takeyama & Masamitsu Sato. Nature Communications (2020 March 09). https://www.nature.com/articles/s41467-020-15060-y

An H3K9 methylation dependent protein interaction regulates the non-enzymatic function of a putative histone demethylase. Gulzhan Raiymbek, Sojin An, Nidhi Khurana, Saarang Gopinath, Ajay Larkin, Saikat Biswas, Raymond C Trievel, Uhn-soo Cho, Kaushik Ragunathan. eLife 2020 Mar 20. doi: 10.7554/eLife53155

Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway. I-Ju Lee, David Pellman, Journal of Cell Biology (April 2020), https://doi.org/10.1083/jcb.201908232

The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe. Bahjat F. Marayati, Ke Zhang, Cells (April 2020), doi: 10.3390/cells9040955

The Ccr4-Not complex monitors the translatingribosome for codon optimality.Robert Buschauer1,*, Yoshitaka Matsuo2,*, Takato Sugiyama2, Ying-Hsin Chen3, Najwa Alhusaini3, Thomas Sweet3, Ken Ikeuchi1,2, Jingdong Cheng1, Yasuko Matsuki2, Risa Nobuta2, Andrea Gilmozzi1, Otto Berninghausen1, Petr Tesina1, Thomas Becker1, Jeff Coller3,, Toshifumi Inada2,, Roland Beckmann1,. Science (April 2020). DOI: 10.1126/science.aay6912

Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin. Wenbo Dong1, Eriko oya1, Yasaman Zahedi1, Punit prasad 1,2, J. Peter Svensson 1, Andreas Lennartsson1, Karl ekwall1 & Mickaël Durand-Dubief. Nature (2020) https://doi.org/10.1038/s41598-020-63209-y

Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model. Jennifer C. Harr, Christoph D. Schmid, Celia Muñoz-Jiménez, Raquel Romero-Bueno, Véronique Kalck, Adriana Gonzalez-Sandoval, Michael H. Hauer, Jan Padeken, Peter Askjaer, Anna Mattout and Susan M. Gasser. Genes Dev March 5, 2020, doi: 10.1101/gad.332213.119

Human Ebp1 rescues the synthetic lethal growth of fission yeast cells lacking Cdb4 and Nup184. Osemwenkhae OP, Sakuno T, Hirano Y, Asakawa H, Hayashi-Takanaka Y, Haraguchi T and Yasushi Hiraoka. Genes Cells 2020 Feb 12. doi: https://doi.org/10.1101/2020.01.10.902296

Phase separation directs ubiquitination of gene-body nucleosomes. Laura D. Gallego, Maren Schneider, Chitvan Mittal, Anete Romanauska, Ricardo M. Gudino Carrillo, Tobias Schubert, B. Franklin Pugh, Alwin Köhler. Nature 2020 Feb 11. JC April 2 2020
see also News & Views by Nick Gilbert & Fred van Leeuwen

Mammalian RNA Decay Pathways Are Highly Specialized and Widely Linked to Translation. Alex Charles Tuck, Aneliya Rankova, Alaaddin Bulak Arpat, Violeta Castelo-Szekely, David Gatfield, Marc Bühler. Molecular Cell 2020 Feb 10. doi.org/10.1016/j.molcel.2020.01.007

Meiotic gene silencing complex MTREC/NURS recruits the nuclear exosome to YTH-RNA-binding protein Mmi1. Shichino Y, Otsubo Y, Yamamoto M, Yamashita A. PLoS Genet. 2020 Feb 3;16(2):e1008598. doi: 10.1371/journal.pgen.1008598.

Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells. Laetitia Maestroni, Céline Reyes, Mélina Vaurs, Yannick Gachet, Sylvie Tournier, Vincent Géli, and Stéphane Coulon. Nucleic Acids Research, 2020 Jan 25. pii: gkaa043. doi: 10.1093/nar/gkaa043.

Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression. Ditipriya Hazra, Vedrana Andrić, Benoit Palancade, Mathieu Rougemaille, and Marc Graille. Scientific Reports 2020 Jan 23. doi: 10.1038/s41598-020-57872-4

BAF facilitates interphase nuclear envelope repair through recruitment of nuclear transmembrane proteins. Alexandra M. Young, Amanda L. Gunn, Emily M. Hatch bioRxiv 2020 doi: https://doi.org/10.1101/2020.01.10.902296

Hap2–Ino80-facilitated transcription promotes de novo establishment of CENP-A chromatin. Puneet P. Singh, Manu Shukla, Sharon A. White, Marcel Lafos, Pin Tong, Tatsiana Auchynnikava, Christos Spanos, Juri Rappsilber, Alison L. Pidoux and Robin C. Allshire. Genes Dev. 2020 ahead of print. doi/10.1101/gad.332536.119. JC Jan 28 2020

2019

Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance. Holla S, Dhakshnamoorthy J, Folco HD, Balachandran V, Xiao H, Sun LL, Wheeler D, Zofall M, Shiv Grewal. Cell. 2019 Dec 21. pii: S0092-8674(19)31330-3. doi: 10.1016/j.cell.2019.12.004. JC Feb 4 2020

Mkt1 is required for RNAi-mediated silencing and establishment of heterochromatin in fission yeast. Taglini F, Chapman E, van Nues R, Theron E, Elizabeth Bayne. Nucleic Acids Res. 2019 Dec 11. pii: gkz1157. doi: 10.1093/nar/gkz1157.

Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe. Ding DQ, Okamasa K, Katou Y, Oya E, Nakayama JI, Chikashige Y, Shirahige K, Haraguchi T, and Yasushi Hiraoka. Nat Commun. 2019 Dec 6;10(1):5598. doi: 10.1038/s41467-019-13609-0. JC Feb 11 2020

Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe. Ding DQ, Okamasa K, Katou Y, Oya E, Nakayama JI, Chikashige Y, Shirahige K, Haraguchi T, and Yasushi Hiraoka . Nat Commun. 2019 Dec 6;10(1):5598. doi: 10.1038/s41467-019-13609-0.

Native Chromatin Proteomics Reveals a Role for a Specific Nucleoporin in Heterochormatin Organization and Maintenance. Iglesias N, Paulo JA, Tatarakis A, Wang X, Edwards AL, Bhanu NV, Garcia BA, Haas W, Gygi SP, Danesh Moazed. Mol Cell. 2019 Nov 7. doi: 10.1016/j.molcel.2019.10.018. JC Jan 21 2020

RNA–DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast. Yan Hu, Henrietta W. Bennett, Na Liu, Martin Moravec, Jessica F. Williams, Claus M. Azzalin and Megan C. King. Genetics October 1, 2019 vol. 213 no. 2 431-447; https://doi.org/10.1534/genetics.119.302606

Sfh1, an essential component of the RSC chromatin remodeling complex, maintains genome integrity in fission yeast.
Kotomura N, Tsunemine S, Kuragano M, Asanuma T, Nakagawa H, Tanaka K, Yota Murakami. Genes Cells. 2018 Sep;23(9):738-752. JC Oct 15 2019

H3K14 ubiquitylation promotes H3K9 methylation for heterochromatin assembly.
Oya E, Nakagawa R, Yoshimura Y, Tanaka M, Nishibuchi G, Machida S, Shirai A, Ekwall K, Kurumizaka H, Tagami H, Jun-ichi Nakayama. EMBO Rep. 2019 Oct 4;20(10):e48111. JC Oct 08 2019

Search-and-replace genome editing without double-strand breaks or donor DNA
Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis, Alexander A. Sousa, Luke W. Koblan, Jonathan M. Levy, Peter J. Chen, Christopher Wilson, Gregory A. Newby, Aditya Raguram & David R. Liu . Nature (2019) Early advanced online

Epigenetic gene silencing by heterochromatin primes fungal resistance
Torres-Garcia S, Audergon P, Shukla M, White SA,  Pidoux
AL, Robin C. Allshire. BioRxiv doi: https://doi.org/10.1101/808055

HP1 reshapes nucleosome core to promote heterochromatin phase separation.
Sanulli S, Trnka MJ, Dharmarajan V, Tibble RW, Pascal BD, Burlingame AL, Griffin PR, Gross JD, Geeta Narlikar. Nature. 2019 Oct 16 doi: 10.1038/s41586-019-1669-2 JC Nov 12 2019

Vigilin protein Vgl1 is required for heterochromatin mediated gene silencing in Schizosaccharomyces pombe.
Farooq Z, Abdullah E, Banday S, Ganai SA, Rashid R, Mushtaq A, Rashid S, Mohammed Altaf. J Biol Chem. 2019 Sep 25. pii: jbc.RA119.009262

CRISPR-mediated live imaging of genome editing and transcription.
Wang H, Nakamura M, Abbott TR, Zhao D, Luo K, Yu C, Nguyen CM, Lo A, Daley TP, La Russa M, Liu Y, Qi LS. Science. 2019 Sep 20;365(6459):1301-1305

The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse.
Kaaij LJT, Mohn F, van der Weide RH, de Wit E, Marc Bühler. Cell. 2019 Sep 5;178(6):1437-1451.e14

Multiplexed genome engineering by Cas12a and CRISPR arrays encoded on single transcripts.
Campa CC, Weisbach NR, Santinha AJ, Incarnato D, Platt RJ. Nat Methods. 2019 Sep;16(9):887-893

RNA-induced initiation of transcriptional silencing (RITS) complex structure and function.
Bhattacharjee S, Roche B, Rob A Martienssen. RNA Biol. 2019 Sep;16(9):1133-1146

Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast.
Mennie AK, Moser BA, Hoyle A, Low RS, Tanaka K, Toru M Nakamura. Commun Biol. 2019 Aug 7;2:297

Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence.
Oya E, Durand-Dubief M, Cohen A, Maksimov V, Schurra C, Jun-ichi Nakayama, Ronit Weisman, Benoit Arcangioli, Karl Ekwall. Epigenetics Chromatin. 2019 Jul 17;12(1):45

Disordered region of H3K9 methyltransferase Clr4 binds the nucleosome and contributes to its activity.
Akoury E, Ma G, Demolin S, Brönner C, Zocco M, Cirilo A, Ivic N, Mario Halic. Nucleic Acids Res. 2019 Jul 26;47(13):6726-6736

CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.
Vo TV, Dhakshnamoorthy J, Larkin M, Zofall M, Thillainadesan G, Balachandran V, Holla S, Wheeler D, Shiv Grewal. Cell Rep. 2019 Jul 2;28(1):267-281.e5 JC Sep 2019

Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1
Sorida M, Hirauchi T, Ishizaki H, Kaito W, Shimada A, Mori C, Chikashige Y, Hiraoka Y, Suzuki Y, Ohkawa Y, Kato H, Takahata S, Yota Murakami. PLoS Genet. 2019 Jun 17;15(6):e1008129

Improved CUT&RUN chromatin profiling tools
Meers MP, Bryson TD, Henikoff JG, Steve Henikoff. Elife. 2019 Jun 24;8. pii: e46314

Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.
Folco HD, McCue A, Balachandran V, Shiv Grewal. Genetics. 2019 Sep;213(1):127-141

Heterochromatin drives compartmentalization of inverted and conventional nuclei.
Falk M, Feodorova Y, Naumova N, Imakaev M, Lajoie BR, Leonhardt H, Joffe B, Dekker J, Fudenberg G, Irina Solovei, Leonid A Mirny. Nature. 2019 Jun;570(7761):395-399  PMID: 31168090 JC Jun 11 2019

Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei.
Cabianca DS, Muñoz-Jiménez C, Kalck V, Gaidatzis D, Padeken J, Seeber A, Askjaer, Susan M Gasser. Nature. 2019 May;569(7758):734-739. Dept JC Jul 5 2019

Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
Kume K, Cantwell H, Burrell A, Paul Nurse. Nat Commun. 2019 Apr 23;10(1):1871 PMID:31015410

Ssu72 phosphatase is a conserved telomere replication terminator.
Escandell JM, Carvalho ES, Gallo-Fernandez M, Reis CC, Matmati S, Luís IM, Abreu IA, Coulon S, Miguel G Ferreira. EMBO J. 2019 Apr 1;38(7). pii: e100476 PMID: 30796050 JC Apr 9 2019

Inheritance of a phenotypically neutral epimutation evokes gene silencing in later generations.
Duempelmann L, Mohn F, Shimada Y, Oberti D, Andriolloa A, Lochs S, Marc Bühler. Mol. Cell 2019 Mar 5. pii: S1097-2765(19)30099-1 PMID: 30898439 JC Mar 26 2019

A non-enzymatic function associated with a putative histone demethylase licenses epigenetic inheritance.
Raiymbek G, An S, Khurana N, Gopinath S, Trievel R, Cho US, Kaushik Ragunathan. BioRxiv Feb 19. doi: https://doi.org/10.1101/545814  JC Mar 14 2019

Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1.
Leopold K, Stirpe A, Thomas Schalch. Genes Dev 2019 Feb 26 PMID: 30808655 JC Mar 5 2019

Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression.
Padeken J, Zeller P, Towbin B, Katic I, Kalck V, Methot SP, Susan M Gasser SM. Genes Dev 2019 Feb 25 PMID: 30804228

RNA surveillance by uridylation-dependent RNA decay in Schizosaccharomyces pombe.
Chung CZ, Jaramillo JE, Ellis MJ Bour DYN, Seidl LE, Jo DHS, Turk MA Mann MR, Bi Y, Haniford DB, Duennwald ML, Heinemann IU. Nucleic Acids Res. 2019 Apr 8;47(6):3045-3057

An RNA aptamer to HP1/Swi6 facilitates heterochromatin formation at an ectopic locus in S.pombe.
Rani R, Yassen AM, Aarti Sevilimedu. RNA Biology 2019 Feb 22:1-12 PMID: 30794054.

An essential role for dTNP homeostasis following CDK-induced replication stress.
Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, … Bähler J, Carr AM, Tim C. Humphrey. J Cell Sci. 2019 Feb 15. pii: jcs.226969 PMID: 30674555

RAD52 and SLX4 act nonepistatically to enures telomere stability during alternative telomere lengthening.
Verma P, Dilley RL, Zhang, T, Gyparaki MT, Li Y, Roger A Greenberg. Genes Dev. 2019 Feb 1;33(3-4):221-235 PMID: 30692206

Alternative lengthening of telomeres through two distinct break-induced replication pathways.
Zhang JM, Ydav T, Ouyang J, Lan L, Lee Zou. Cell Rep. 2019 Jan 22;26(4):955-968.e3 PMID: 30673617

A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing.
Xie G, Vo TV, Thilainadesan G, Holla S Zhang B, Jiang Y, Lv M, Xy Z Wang C, Balachandran V, Shi Y, Fudong Li, Shiv Grewal.   Nat Commun. 2019 Jan 16; 10(1):251 PMID: 30651569 JC Jan 29 2019

H3K9me3-heterochromatin loss at protein-coding genes enables devlopmental lineage specification.
Nicetto D, Donahue G, Jain T …  Bonasio R, Jenuwein T, and Ken Zaret.   Science 2019 Jan 18;363(6424):294-297 PMID: 30606806 Dept JC Feb 15 2019

RNA-binding porteins distinguish between similar sequences motifs to promote targeted deadeynlation by Ccr4-Not. Webster MW, Stowell JA, Lori Passmore. Elife 2019 Jan 2;8. pii: e40670 PMID: 30601114

Anti-Silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.
Bao K, Shan CM, Moresco J, Yates J 3rd, Songtao Jia.   Genes Dev. 2019 Jan 1 PMID: 30573453 JC Jan 8 2019

2018

Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.
Hu C, Inoue H, Sun W, Takeshita Y, Huang Y, Xu Y, Kanoh J, Yong Chen. Nucleic Acids Res. 2018 Nov 20. doi: 10.1093/nar/gky1186 PMID: 304623017 JC Nov 27 2018

Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C, Boisvert FM, Telekawa C, Boisvert FM, Francois Bachand. Nucleic Acids Res. 2018 Oct 13. doi: 10.1093/nar/gky915. PMID: 30321377

Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation.
Marcomini I, Shimada K, Delgoshaie N, Yamamoto I, Seeber A, Cheblal A, Horigome C, Naumann U, Susan M Gasser.   Cell Rep. 2018 Sep 4;24(10):2614-2628.e4. PMID:30184497 JC Sept 25 2018

Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stabilty.
Iglesias N, Currie MA, Jih G, Paula JA, Siuti N, Kolcsay M, Gyig SP, Danesh Moazed. Nature. 2018 Aug 23; 560(7719). PMID: 30051891 JC Nov 6 2018

The binding of Chp2’s chromodomain to methylated H3K9 is essential for Chp2’s role in heterochromatin assembly in fission yeast.
Maksimov V, Oya E, Tanaka M, Kawaguchi T, Hachisuka A, Ekwall K, Bjerling P, Jun-ichi Nakayama. PLoS One. 2018 Aug 15;13(8):e0201101. eCollection 2018. PMID: 30110338

Long non-coding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.
Atkinson SR, Marguerat S, Bitton DA, Rodríguez-López M, Rallis C, Lemay JF, Cotobal C, Malecki M, Smialowski P, Mata J, Korber P, Bachand F, Jürg Bähler. RNA 2018 Sep;24(9):1195-1213 PMID: 29914874 JC Apr 23 2019

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.
Yang J, Sun S, Zhang S, Gonzalez M, Dong Q, Chi Z, Chen YH, Fei Li. PLoS Genet. 2018 Aug 8;14(8):e1007572. PMID:30089114 JC Sept 6 2018

Ccp1 modulates epigenetic stability at centromeres and affects heterochromatin distribution in Schizosaccharomyces pombe.
Lu M, Xiangwei He. JBC 2018 Aug 3;293(31):12068-12080 PMID: 29899117. JC Jun 4 2019

Shelterin promotes tethering of late replication origins to telomeres for replication-timing control.
Ogawa S, Kido S, Handa T, Ogawa H, Asakawa H, Takahashi TS, Nakagawa T, Hiraoka Y, Masukata H. EMBO J. 2018 Aug 1;37(15). PMID: 29997179

Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Danesh Moazed Nature. 2018 Aug;560(7719):504-508. PMID: 30051891 JC Nov 6 2018

Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA. Greenwood J, Patel H, Cech TR, Julie Cooper.
Nucleic Acids Res. 2018 Jul 10.  PMID: 29992245 JC Dec 18 2018

Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.
Greenstein RA, Jones SK, Spivey EC, Rybarski JR, Finkelstein IJ, Bassem Al-Sady. Elife. 2018 Jul 18;7. PMID: 30020075

Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly.
Parsa JY, Boudoukha S, Burke J, Homer C, Hiten Madhani
Genes Dev. 2018 Jul 1;32(13-14):953-964.  PMID: 29967291  JC Oct 2 2018

The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast. Seo HD, Kwon CS, Daeyoup Lee. Current Genetics. 2018 Jun 64;3. PMID: 29214404

Histone deacetylation promotes transcriptional silencing at facultative heterochromatin.
Watts BR, Wittmann S, Wery M, Gautier C, Kus K, Birot A, Heo DH, Kilchert C, Morillon A, Lydia Vasiljeva.   Nucleic Acids Res. 2018 Jun 20;46(11):5426-5440. PMID:29618061  JC May 29 2018

Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.
Yu R, Wang X, Danesh Moazed.   Nature. 2018 Jun;558(7711): 615-619. PMID: 29925950 JC Feb  26 2019

TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres.
Cohen A, Habib A, Laor D, Yadav S, Kupiec M, Ronit Weisman
J Biol Chem. 2018 May 25;293(21):8138-8150. PMID:29632066

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.
Matmati S, Vaurs M, Escandell JM, Maestroni L, Nakamura TM, Ferreira MG, Géli V, Coulon S. Sci Adv. 2018 May 16;4(5):eaar 2740. JC Jul 2019

Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control.
Gallagher PS, Larkin M, Thillainadesan G, Dhakshnamoorthy J, Balachandran V, Xiao H, Wellman C, Chatterjee R, Wheeler D, Shiv Grewal.   Nat Struct Mol Biol. 2018 May;25(5):372-383. PMID:29686279 JC Nov 13 2018

Distinct ‘safe zones’ at the nuclear envelope ensure robust replication of heterochromatic chromosome regions.
Ebrahimi H, Masuda H, Jain D, Julie Cooper. Elife. 2018 May 3;7. PMID:29722648  JC Jul 24 2018

RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes.
Begnis M, Apte MS, Masuda H, Jain D, Wheeler DL, Julie Cooper. Genes Dev. 2018 Apr 1;32(7-8):537-554.PMID:29654060  JC May 22 2018

The conserved histone variant H2A.Z illuminates meiotic recombination initiation.
Yamada S, Kugou K, Ding DQ, Fujita Y, Yasushi Hiraoka, Murakami H, Ohta K, Yamada T. Curr Genet. 2018 Mar 16. PMID: 29549582

Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast.
Páez-Moscoso DJ, Pan L, Sigauke RF, Schroeder MR, Tang W, Peter Baumann. Nat Commun. 2018 Feb 8;9(1):587. PMID: 29422664 JC Apr 30 2019

Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast.
Hirano Y, Kinugasa Y, Asakawa H, Chikashige Y, Obuse C, Haraguchi T, Yasushi Hiraoka. Genes Cells. 2018 Mar;23(3):122-135. Epub 2018 Jan 2. PMID:29292846  JC Jan 23 2018

Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast.
Ren B, Tan HL, Nguyen TTT, Sayed AM, Li Y, Mok YK, Yang H, Ee Sin Chen. Nucleic Acids Res. 2018 Jan 9;46(1):189-202. PMID:29136238  JC Dec 12 2017

2017

Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi.
Kajitani T, Kato H, Chikashige Y, Tsutsumi C, Hiraoka Y, Kimura H, Ohkawa Y, Obuse C, Hermand D, Yota Murakami. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52). PMID: 29237752

Host factors that promote retrotransposon integration are similar in distantly related eukaryotes.
Rai SK, Sangesland M, Lee M, Esnault C, Cui Y, Chatterjee AG, Henry L. Levin. PLOS Genetics 2017 Dec 12;13(12):e1006775. PMID: 29232693 JC May 28 2019

Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences.
Maestroni L, Audry J, Matmati S, Arcangioli B, Géli V, Stephane Coulon. Nat Commun. 2017 Nov 22;8(1):1684. PMID: 29167439  JC Dec 19 2017

The Ino80 complex mediates epigenetic centromere propagatio via active removal of histone H3.
Choi ES, Cheon Y, Kang K, Daeyoup Lee. Nat Commun. 2017 Sep 13;8(1):529. PMID:28904333  JC Feb 20 2018

Ubiquitination-dependent control of sexual differenation in fission yeast. Simonetti F, Candelli T, Leon S, Libri D, Mathieu Rougemaille. eLIFE. 2017;6:e28046. PMID:28841135 JC Sept 11 2018

Accumulation of RNA on chromatin disrupts heterochromatic silencing.
Brönner C, Salvi L, Zocco M, Ugolini I, Mario Halic. Genome Res. 2017 Jul;27(7):1174-1183. PMID:28404620  JC June 20 2018

LTR-Retrotransposon Control by rRNA-Derived Small RNAs.
Schorn AJ, Gutbrod MJ, LeBlanc C, Rob Martienssen. Cell. 2017 Jun 29;170(1):61-71.e11. PMID:28666125  JC Nov 14 2017

DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 mehtylation.
Wang X,  Danesh Moazed. Science. 2017 Apr 7, 356(6333). PMID: 28302794  JC Nov 24 2017

Chromatin remodeller Fun30 (Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, Choi ES, Seo HD, Kang K, Gilmore JM, Florens L, Washburn MP, Choe J, Workman JL, Daeyoup Lee. Nat Commun. 2017 Feb 20;8:14527.PMID:28218250  JC March 14 2017

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