Our main interest is the spatial and temporal regulation of heterochromatin, a transcriptionally inactive (silent) form of chromatin that is crucial for cellular differentiation, genome stability and chromosome organization.
We seek to address which factors contribute to heterochromatin regulation, how they cooperate, and what are the underlying mechanisms by which they shape and control heterochromatin.
For this, we employ genetics and functional genomics to identify novel factors and assign them to functional pathways and regulatory networks. Using live-cell imaging, molecular biology and biochemistry, we further seek to understand the underlying mechanisms of regulation. As a model, we use the fission yeast (Schizosaccharomyces pombe). This powerful model organism can be easily and precisely manipulated while it shares many of the hallmarks of heterochromatin present in higher eukaryotes. This allows us applying advanced genomics to dissect conserved pathways of heterochromatin regulation.
Our lab is highly international and part of the Department of Physiological Chemistry of the Ludwig-Maximilians-Universität (LMU) Munich. We are located in the Biomedical Center (BMC) on the Martinsried Campus in the south of Munich. We are directly next to the BioCenter and the Max Planck Institutes of Biochemistry and Neurobiology, and in close proximity to the Gene Center and Helmholtz Institute of the Grosshadern Campus.
Networks & Funding
We are part of the Innovative Training Network (ITN) “Cell2Cell that investigates how cell-to-cell heterogeneity in chromatin structure promotes adaptation to changes in the environment. We are further member of the collaborative research center Chromatin Dynamics (SFB 1064) and its integrated research training program (IRTG) for PhD students. In addition, our lab is associated with the International Max Planck Research School for Molecular Life Sciences (IMPRS-LS). We have been member of the former European Network of Excellence Epigenesys.
Our research is funded by the Marie-Curie Skłodowska Actions of the European Commission (EC), by the Deutsche Forschungsgemeinschaft (DFG) and the Friedrich Baur Stiftung.