800 million years of co-evolution in the green plant lineage: the case of LEUNIG and SEUSS transcriptional co-regulators.
Garrecht J, Rössner C, Sreechakram VN, Li Q, Braun S, Golz JF, Becker A (2026)
Molecular Biology and Evolution, Volume 43, Issue 7, July 2026, msag154, https://doi.org/10.1093/molbev/msag154
Nucleosome remodeling by a CHD enzyme promotes H3K9 methylation establishment and spreading via remodeler-writer feedback. Preprint
Seman M, Latuda A, Mazumder A, Wolfstädter LM, Huang F, Abdulla AZ, Braun S, Ragunathan K (2026)
bioRxiv 2026.05.03.722496; doi: https://doi.org/10.64898/2026.05.03.722496
RNAi-based discrimination of exogenous DNA by mitotic heterochromatin in fission yeast. Preprint
Ebina H, Valentini M, Yu H, Baumgartner L, Olsen KCF, Rajeswaran R, Braun S, Voinnet O, Barral Y (2026)
bioRxiv 2026.03.26.714489; doi: https://doi.org/10.64898/2026.03.26.714489
Nuclear Dynamics in Quiescent Cells: Conserved Mechanisms from Yeasts to Mammals. Review
Braun S, Kilchert C, Bulut-Karslioglu A, Ruault M, Taddei A, Rabbani F, Włoch-Salamon D (2026)
Biomolecules. 16(2):203. https://doi.org/10.3390/biom16020203
MCUR1–CCDC90B complex is a conserved mitochondrial scaffold regulating metabolic homeostasis. Preprint
J Verissimo Ferreira, J Wettmarshausen, V Goh, K Lagerborg, J Watrous, MS Feng, H Delgado de la Herran, S Walia, Y Cheng, A Leimpek, M Gorza, S Braun, R Nilsson, M Jain, M Mann, D Mokranjac, M Murgia, TB Haack, M Deschauer, H Prokisch, FV Filipp, F Perocchi (2025)
bioRxiv 2025.10.14.682030; doi: https://doi.org/10.1101/2025.10.14.682030
Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin. Preprint
Mazumder A, Cooper J, Goksal C, Khanduja JS, Joh RI, Groos JJ, Brockhausen RYJ, Kanoh J, Motamedi M, Finkelstein IJ, Al-Sady B, Braun S (2025).
bioRxiv 2025.09.25.678047; https://doi.org/10.1101/2025.09.25.678047
A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Merle Skribbe, Charlotte Soneson, Michael B. Stadler, Michaela Schwaiger, Vishnu N. Suma Sreechakram, Vytautas Iesmantavicius, Daniel Hess, Eliza Pandini Figueiredo Moreno, Sigurd Braun, Jan Seebacher, Sebastien A. Smallwood, Marc Bühler (2025)
Molecular Cell, Volume 85, Issue 7, 2025 Pages 1426-1444.e8, ISSN 1097-2765, https://doi.org/10.1016/j.molcel.2025.01.032.
Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation
Alberto Jiménez-Martín, Alberto Pineda-Santaella, Rebeca Martín-García, Rodrigo Esteban-Villafañe, Alix Matarrese, Jesús Pinto-Cruz, Sergio Camacho-Cabañas, Daniel León-Periñán, Antonia Terrizzano, Rafael R. Daga, Sigurd Braun & Alfonso Fernández-Álvarez (2025)
Nat Commun 16, 837 https://doi.org/10.1038/s41467-025-56049-9
High-throughput FLIM flow cytometry with a continuous-wave laser.
Kanno H, Hiramatsu K, Mikami H, Nakayashiki A, Yamashita S, Nagai A, Okabe K, Li F, Braun S, Houston JP, Rashad S, Niizuma K, Godal K (2024)
Proc. SPIE PC13330, High-Throughput Biophotonics: Imaging, Spectroscopy, and Beyond X, PC133300B; https://doi.org/10.1117/12.3041561
A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation.
Muhammad A, Sarkadi Z, Mazumder A, Ait Saada A, van Emden T, Capella M, Fekete G, Suma Sreechakram VN, Al-Sady B, Lambert SAE, Papp B, Barrales RR, Braun S (2024).
Nucleic Acids Res. 52(22):13665-13689. doi: https://doi.org/10.1093/nar/gkae1024.
Heterochromatin as a balancing act between transcription and gene silencing.
Braun S.
Nat Rev Mol Cell Biol 25, 676 (2024). https://doi.org/10.1038/s41580-024-00762-8
The inner nuclear membrane Lem2 coordinates RNA degradation at the nuclear periphery.
Martín Caballero L, Capella M, Barrales RR, Dobrev N, van Emden T, Hirano Y, Suma Sreechakram VN, Fischer-Burkart S, Kinugasa Y, Nevers A, Rougemaille M, Sinning I, Fischer T, Hiraoka Y, and Braun S (2022)
Nature Struct & Mol Biol 2022 29(9):910-921. doi: https://doi.org/10.1038/s41594-022-00831-6
Proteome effects of genome-wide single gene perturbations.
Öztürk M, Freiwald A, Cartano J, Schmitt R, Dejung M, Luck K, Al-Sady B, Braun S, Levin M, & Butter F (2022)
Nature communications, 13(1), 6153. https://doi.org/10.1038/s41467-022-33814-8
Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction.
Greenstein RA, Ng H, Barrales RR, Tan C, Braun, S., & Al-Sady B (2022).
PLoS genetics, 18(5), e1010201. https://doi.org/10.1371/journal.pgen.1010201
Chaperoning heterochromatin: new roles of FACT in chromatin silencing. Mini-Review
Murawska M, and Braun S (2022).
Trends in genetics : TIG, 38(7), 646–649. https://doi.org/10.1016/j.tig.2022.02.011
Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.
Capella M, Mandemaker I, Martín Caballero L, den Brave F, Pfander B, Ladurner A.G, Jentsch S, Braun S
Nat Commun 12, 4918 (2021). doi: https://doi.org/10.1038/s41467-021-25205-2
Crosstalk between H2A variant-specific modifications impacts vital cell functions.
Anna Schmücker, Bingkun Lei, Zdravko J. Lorković, Matías Capella, Sigurd Braun, Pierre Bourguet, Olivier Mathieu, Karl Mechtler, Frédéric Berger
PLoS Genet 17(6): e1009601. https://doi.org/10.1371/journal.pgen.1009601
A Synthetic Approach to Reconstruct the Evolutionary and Functional Innovations of the Plant Histone Variant H2A.W.
Lei B, Capella M, Montgomery S, Borg M, Osakabe A, Goiser M, Muhammad A, Braun S, Berger F (2021)
Current Biology Jan 11;31(1):182-191.e5. doi: https://doi.org/10.1016/j.cub.2020.09.080.
ESCRT recruitment by the inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
Capella M, Martín Caballero L, Pfander B, Braun S*, and Jentsch S.
J Cell Sci. 2020 Dec 21;133(24):jcs250688. doi: 10.1242/jcs.250688.
See also additional information on first-author Matías Capella
ESCRTing Heterochromatin Out of the Nuclear Periphery. Preview
Capella M and Braun
Developmental Cell Volume 53, Issue 1, 6 April 2020, Pages 3-5 https://doi.org/10.1016/j.devcel.2020.03.013
The euchromatic histone mark H3K36me3 preserves heterochromatin through sequestration of an acetyltransferase complex in fission yeast.
Georgescu PR, Capella M, Fischer-Burkart S and Braun S
Microbial Cell 2020 Vol. 7, No. 3, pp. 80 – 92; doi: https://doi.org/10.15698/mic2020.03.711
Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability.
Greenstein RA, Barrales RR, Sanchez NA, Bisanz JE, Braun S, Al-Sady B
Genes & Development 2019 Dec 5. doi: https://doi.org/10.1101/gad.328468.119.
Neutral epigenetic inheritance: being prepared for future generations. Preview
Capella M and Braun S.
Nat Struct Mol Biol 2019 May 20. doi: https://doi.org/10.1038/s41594-019-0239-5.
TASks for subtelomeres: when nucleosome loss and genome instability are favored. Mini-review
van Emden TS and Braun S
Curren Genetics 2019 May 7. doi: https://doi.org/10.1007/s00294-019-00986-8.
Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability.
van Emden TS*, Forn M*, Forné I, Sarkadi Z, Capella M, Martín Caballero L, Fischer-Burkart S, Brönner C, Simonetta M, Toczyski D, Halic M, Imhof A, and Braun S
EMBO Reports 2019 Jan;20(1). pii: e47181. doi: https://doi.org/10.15252/embr.201847181 *co-first authors
The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S, Gallardo P, Barrales RR, Braun S, Daga RR.
J Cell Biol. 2017 Oct 3. doi: https://doi.org/10.1083/jcb.201612194.
The histone acetyltransferase Mst2 protects active chromatin from epigenetic silencing by acetylating the ubiquitin ligase Brl1.
Flury V, Georgescu PR, Iesmantavicius V, Shimada Y, Kuzdere T, Braun S*, and Bühler M*
Molecular Cell 2017 Jul 20;67(2):294-307.e9. doi: https://doi.org/10.1016/j.molcel.2017.05.026. *co-corresponding authors
Beyond Tethering and the LEM domain: MSCellaneous functions of the inner nuclear membrane Lem2. Mini-review
Braun S*, Barrales RR.
Nucleus 2016 Nov;7(6):523-531 doi: https://doi.org/10.1080/19491034.2016.1252892.
*corresponding author
Chromatin binding and silencing: Two roles of the same protein Lem2.
Barrales RR , Braun S. Commentary.
Microbial Cell 2016 Apr 4;3(4):185-188 doi: https://doi.org/10.15698/mic2016.04.495.
Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics.
Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD.
PLoS One 2016 Aug 1;11(8):e0159292. https://doi.org/10.1371/journal.pone.0159292
Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.
Barrales RR, Forn M, Georgescu PR, Sarkadi Z, and Braun S.
Genes & Development 2016 Jan 15;30(2):133-48.. doi: https://doi.org/10.1101/gad.271288.115
Global regulation of heterochromatin spreading by Leo1.
Verrier L, Taglini F, Barrales RR, Webb S, Urano T, Braun S, and Bayne EH.
Open Biology 2015 May;5(5): pii: 150045. doi: 1 https://doi.org/0.1098/rsob.150045.
Relationship between genome and epigenome—challenges and requirements for future research. Commentary
Almouzni G, Altucci, L, Amati B, Ashley N, Baulcombe D, Beaujean N, Bock C, Bongcam-Rudloff E, Bousquet J, Braun S et al.
BMC Genomics 2014 Jun 18;15:487. doi: https://doi.org/10.1186/1471-2164-15-487.
Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin. Review
Braun S* and Madhani HD.
EMBO reports, 13(7), 619–630. https://doi.org/10.1038/embor.2012.78 *corresponding author
Ers1 links HP1 to RNAi.
Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11258-63. doi: https://doi.org/0.1073/pnas.1204947109
The ubiquitin ligase Cul4-Ddb1Cdt2 inhibits the invasion of a boundary-associated anti-silencing factor into heterochromatin.
Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD.
Cell 2011 Jan 7;144(1):41-54. doi: 1 https://doi.org/0.1016/j.cell.2010.11.051.
Ers1, a rapidly diverging protein essential for RNA interference-dependent heterochromatic silencing in Schizosaccharomyces pombe.
Rougemaille M, Shankar S, Braun S, Rowley M, Madhani HD.
J Biol Chem. 2008 Sep 19;283(38):25770-3. doi: https://doi.org/10.1074/jbc.C800140200
A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.
Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS.
Nat Methods 2008 Aug;5(8):711-8. doi: https://doi.org/10.1038/nmeth.1234.
PhD & before
SM-protein-controlled ER-associated degradation discriminates between different SNAREs.
Braun S, Jentsch S.
EMBO Reports 2007 Dec;8(12):1176-82. https://doi.org/10.1038/sj.embor.7401105
A Series of Ubiquitin-Binding Factors Connects Cdc48/p97 to Substrate Multiubiquitylation and Proteasomal Targeting.
Richly H, Rape M, Braun S, Rumpf S, Hoege C and Jentsch S.
Cell 2005 Jan 14;120(1):73-84. https://doi.org/10.1016/j.cell.2004.11.013
Role of the Ubiquitin-selective Cdc48Ufd1-Npl4 chaperone (segregase) in ERAD of Ole1 and other substrates.
Braun S, Matuschweski K, Rape M, Thoms S and Jentsch S.
EMBO Journal 2002 Feb 15;21(4):615-21. https://doi.org/10.1093/emboj/21.4.615
Dexamethasone-enhanced sensitivity of mouse hippocampal HT22 cells for oxidative stress is associated with the suppression of nuclear factor-kappaB.
Braun S, Liebetrau W, Berning B, Behl C.
Neuroscience Letters 2000 Dec 8;295(3):101-4. https://doi.org/10.1016/S0304-3940(00)01603-7
Glutathione and a UV light-induced glutathione S-transferase are involved in signaling to chalcone synthase in cell cultures.
Loyall L, Uchida K, Braun S, Furuya M, Frohnmeyer H.
Plant Cell 2000 Oct;12(10):1939-50. https://doi.org/10.1105/tpc.12.10.1939